Comprehensive definition of human immunodominant CD8 antigens in tuberculosis
نویسندگان
چکیده
منابع مشابه
Immunodominant Tuberculosis CD8 Antigens Preferentially Restricted by HLA-B
CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these pathogens remains poorly characterized. Tuberculosis (TB), the disease caused by Mtb infection, remains one of the leading causes of infectious morbidi...
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A serological survey was performed in groups of patients with active sputum smear-positive or smear-negative pulmonary tuberculosis, healthy household contacts, and controls. Sera were tested for titers of antibodies which bound to each of five purified mycobacterial antigens by enzyme immunoassay and for competition of binding to single epitopes, using six radiolabeled monoclonal antibodies di...
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ژورنال
عنوان ژورنال: npj Vaccines
سال: 2017
ISSN: 2059-0105
DOI: 10.1038/s41541-017-0008-6